To determine whether the VAANX shares the same risk haplotypes with VAND, we conducted haplotype analyses with the VAANX sample. A brief summary of these analyses is listed in Table 6, and complete results were shown in eTable 2. In these analyses, combinations 7-9-10 and 5-7-9-10 showed female-specific associations with both SI and the FTND (Table 6). The haplotypes associated with the FTND were the same (1-1-2 and 1-1-1-2 for combinations 7-9-10 and 5-7-9-10, respectively) as those found in the VAND sample, but the haplotypes associated with SI were not. Given the 8 independent tests estimated by the SNPSpD program and the 3 haplotype tests, the corrected threshold for significance would be .05/11 = .004545. Because our replication was in the same haplotype and same sex, we arguably could use a 1-tailed test criterion (ie, the threshold of 2 × 0.004545 or 0.00909). Using this criterion, the association of the FTND with haplotype 1-1-2 of combination 7-9-10 just met this threshold. All other tests failed multiple testing correction.
