Chunk #17 — METHODS — Coordinated meta-analysis process — VI. Models Analyzed

Source

Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression.

Embedded

yes

Text

Additional secondary hypotheses (e.g., whether there is a main effect of 5-HTTLPR variation on depression, whether the effect is observed when using a dominant model (LL vs SL or SS), whether the effect would be observed more strongly in a single sex) were also examined to improve our understanding of this complex topic.