Support for the hypothesis that S alleles are associated with an increased risk for depression in stress-exposed individuals, but not in individuals who are unexposed to stress, would be reflected by an OR > 1 for the gene × stress interaction term. We examined this main hypothesis in multiple settings in an attempt to determine a range of conditions under which the effect might be found. We examined two types of stress (childhood maltreatment, other life stress), two categories of depression (depression during lifetime, current depression), and two age ranges (all ages, young adults between the ages of 21 and 30).
