When investigating these loci in diverse ethnic populations such as African-American and Hispanic groups, three potential outcomes are possible. First, association of the same polymorphism at the same locus may be confirmed. Second, a different polymorphism at the same locus may be associated in differing ethnicities. Finally, loci identified in cohorts of European ancestry may not replicate in individuals of non-European ancestry, suggesting that unique loci in the genome are responsible for blood lipid traits in groups of differing ancestries.
