Genome-wide association (GWA) studies in subjects of European ancestry have successfully identified genetic loci associated with plasma level of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and/or triglycerides. We and others recently identified single nucleotide polymorphisms (SNPs) at 19 loci as associated with blood lipids; eight of these loci were novel.1–6 However, the relevance of these variants in the diverse U.S. population is unclear.
