For most of the recommended genes, only variants that have been previously reported and are a recognized cause of the disorder or variants that are previously unreported and are of the type which is expected to cause the disorder have been recommended for analysis and reporting, and an argument could be made for the examination and reporting of a broader range of novel variation predicted informatically to be of possible significance. However, because informatics tools are still unreliable predictors of variant impact, particularly for missense variants, and because incidental findings are, by definition, identified in persons outside of the clinical indication for testing, these patients are at a low prior probability of being affected by the conditions in the Table. The conditions and variant thresholds we selected for reporting incidental findings have therefore been set to try to maximize the benefits (increasing the likelihood of true positive results) and minimize the harms (decreasing the likelihood of false positive results).
