The ACMG recommends that for any evaluation of clinical sequencing results, all of the genes and types of variants in the Table should be examined and the results reported to the ordering clinician. The conditions listed in the Table are those that the Working Group and external reviewers considered most likely to be verifiable by other diagnostic methods and amenable to medical intervention based on current evidence and the clinical consensus of the Working Group members. Reporting these incidental findings to the ordering clinician will offer the clinician, or an appropriate consulting clinician, the opportunity to re-evaluate the patient’s personal and family history and consider appropriate surveillance or intervention for patients and their family members who are deemed to be at increased risk for these conditions. These recommendations should be understood to represent a minimum list that is a starting point for the selection and reporting of incidental findings, fully acknowledging that as additional evidence and expertise are applied, these recommendations will require ongoing modification. The ACMG recognizes that laboratories may need to take some time to implement these recommendations.
