One difficulty with interpretations of brain function gained from a number of neuroscientific techniques, including the lesion method, is that they tend to encourage focus on a single area in isolation rather than allowing consideration of how a particular region works in concert with others to guide behaviour. As was discussed earlier, the ACC and OFC have frequently been co-activated in neuroimaging studies of outcome monitoring, though the evidence from Walton and colleagues (2004) is that their contribution may be dissociated depending on whether choices are made voluntarily or through external guidance, a finding supported by the anatomical connections of these two regions (Croxson, Johansen-Berg, Behrens, Robson, Pinsk, et al., 2005).
