The discovery of common genetic variants associated with risk for psychiatric illness has the capability of restarting hypothesis-led drug discovery. As for other complex genetic disorders, the application of human genetics to schizophrenia, led by the PGC (URLs), has identified multiple disease susceptibility loci with increasing sample sizes. In 2014, over 100 robustly associated loci were identified through case-control GWAS meta-analysis by the PGC10. Similar progress is underway in other psychiatric disorders, with new successful GWAS reports expected for ADHD, autism, major depressive disorder, anorexia nervosa, and bipolar disorder in the next year.
