Chunk #32 — RESULTS — Differential expression of signaling proteins in calcium, cyclic nucleotide and small GTPase 2nd messenger pathways in PCPs — Ras and Rho small GTPases
term cellular changes. Furthermore, both the Rho-GTPases and Rho-GEFs are differentially expressed. 37 of the 57 Rho-GEFs (AUROC=0.82) and 14 of the 19 Rho-GTPases (AUROC=0.72) are enriched in specific PCPs (Figure 5D, S5C-D). As different Rho members are often activated by designated GEFs (Cook et al., 2014), differential expression of Rho signaling and regulatory components might provide the mechanism and capacity to maintain diversity of GABAergic neuron morphology, connectivity, and to support different forms of neurite and synaptic motility and plasticity.
