Chunk #33 — RESULTS — Differential expression of signaling proteins in calcium, cyclic nucleotide and small GTPase 2nd messenger pathways in PCPs — Ras and Rho small GTPases
Together, our results suggest that, among the vast number of intracellular signaling proteins constituting myriad pathways that transduce major categories of extracellular inputs, a small number of regulatory components encoded by just a few gene families are differentially expressed among PCPs and likely customize a handful of 2nd messenger pathways. Superimposed upon the core common signaling scheme, these regulatory components likely shape the specificity and spatiotemporal dynamics of broadly acting 2nd messengers to translate specific inputs to appropriate cellular responses.
