differences (95 % C.I.) p p for gender interactiona Whole sample Conduct problems (0–10)0.16 (0.06,0.26)0.0020.05 (−0.06,0.15)0.4060.105 Hyperactivity/inattention (0–10)0.27 (0.12,0.43)0.0010.11 (−0.05,0.27)0.1780.082 Total problems (0–40)0.68 (0.33,1.03)<0.0010.30 (−0.07,0.67)0.1090.022Boys Conduct problems (0–10)0.08 (−0.07,0.22)0.314−0.06 (−0.21,0.10)0.460 Hyperactivity/inattention (0–10)0.14 (−0.09,0.36)0.245−0.02 (−0.26,0.23)0.889 Total problems (0–40)0.27 (−0.23,0.78)0.288−0.16 (−0.69,0.37)0.565Girls Conduct problems (0–10)0.24 (0.11,0.37)<0.0010.16 (0.01,0.31)0.034 Hyperactivity/inattention (0–10)0.40 (0.20,0.60)<0.0010.25 (0.04,0.47)0.022 Total problems (0–40)1.08 (0.61,1.56)<0.0010.80 (0.29,1.31)0.002 aIn unadjusted model bAdjusted for (multivariable analysis n = 4,183): maternal age, parity, highest level of maternal education, daily frequency of smoking during the second trimester, use of cannabis and/or other illicit drugs in pregnancy, home ownership, whether currently married, high scores (>12) on the Edinburgh Postnatal Depression Scale, and child gestational age, birth weight and gender Table 3Relationships between binge pattern of drinking (yes/no) and mean differences (regression coefficients) in teacher-rated SDQ and Key stage 2Outcome measures (score range)Unadjusted mean differences (95 % C.I.) p Adjustedb mean differences (95 % C.I.) p p for gender interactiona Conduct problems (0–10)0.17 (0.06,0.28)0.003−0.03 (−0.15,0.08)0.5460.151Hyperactivity/inattention (0–10)0.36 (0.17,0.54)<0.0010.11 (−0.08,0.29)0.2550.860Total problems (0–40)0.43 (0.02,0.83)0.039−0.20 (−0.61,0.21)0.3320.652Key stage 2−1.82 (−1.31,−2.32)<0.001−0.32 (−0.82,0.18)0.2120.275 aIn unadjusted model bAdjusted for (multivariable analyses: teacher-rated SDQ n = 3,726; Key stage 2 n = 6,035): maternal age, parity, highest level of maternal education, daily frequency of smoking during the second trimester,
