Cumulative probability estimates of remission were high for all the substances assessed, however these estimates should be interpreted with caution given the irregular course of addictions punctuated by remissions and relapses. Social factors, such as the progressive adoption of adult roles and responsibilities [30] and increased contact with environments in which substance dependence has lower acceptability may exert a powerful influence on the likelihood of experiencing remission. Age-related decreases in impulsivity and other neurodevelopmental changes [31], increased self-efficacy to abstain, and awareness of the health-related, social, and judicial [32–34] consequences of substance use are also likely contributors of remission.
