In a large, nationally representative sample of US adults, we found that: 1) the vast majority of individuals with lifetime dependence on nicotine, alcohol, cannabis or cocaine would remit at some point in their lives; 2) remission from cannabis or cocaine dependence occurred faster than remission from nicotine or alcohol dependence; 3) significant racial-ethnic differences were observed in the cumulative probability of remission from nicotine dependence and cocaine dependence; and, 4) several socio-demographic, psychopathological and drug use-related predictors of remission were shared by at least two substances.