and rs938682 / rs8042374 appear to tag different blocks of LD (respective r2 values for: rs938682- rs12914385, rs938682- rs8042374 rs12914385-rs8042374 are 0.22, 1.00 and 0.22 based on HapMap CEU, and 0.18, 0.99, and 0.17 based on UK-GWA Phase 2 controls). The possibility of two independently acting loci is supported by logistic regression whereby the ORs for rs12914385 were 1.29 (Ptrend = 4.79 ×10−16) and 1.20 (Ptrend = 1.81 ×10−7) without and with adjustment for rs8042374. Similarly the ORs for rs8042374 were 0.75 (Ptrend = 5.82 ×10−15) and 0.82 (Ptrend = 2.13 ×10−6) without and with adjustment for rs12914385 (Table 1).
