At 5p15.33 the best evidence for an association was provided by rs4975616 (OR = 0.86, 95% CI: 0.81–0.91; P = 6.66 ×10−7; Supplementary Table 1) which localizes within a 60kb region of LD (1,353,580–1,412,838bp) between TERT and CLPTM1L (Figure 2b). It has been proposed that 5p15.33 harbours two independent loci for lung cancer risk(5). The first is defined by rs402710 which maps within intron 16 of CLPTM1L and is in strong LD with rs4975616 (r2 = 0.53 based on HapMap CEU; r2 = 0.55 based on UK-GWA Phase 2 controls). The second association signal is defined by rs2736100 which maps within intron 2 of TERT. In our combined data series the association between rs2736100 and lung cancer risk was however, weak: OR = 0.96 (Ptrend = 0.19) and OR = 0.97 (Ptrend = 0.37) without and with adjustment for rs4975616 (Supplementary Table 3).
