The strongest evidence for a relationship between genetic variation at 6p21.33 and lung cancer risk was attained at rs3117582 and rs1150752 (OR = 1.24, 95% CI: 1.14–1.35; P = 9.13 ×10−7; 11 OR = 1.24, 95% CI: 1.13−1.35; P = 1.93 × 10−6, respectively; Supplementary Table 1). rs3117582 (31,728,499bp) localizes to intron 1 of BAT3 and rs1150752 (32,172,704bp) localises to exon 3 of TNXB (Figure 2c). Genotypes are highly correlated (r2 = 0.73 based on HapMap CEU; r2 = 0.91 based on UK-GWA Phase 2 controls) and on the basis of flanking recombination hotspots define a single locus at 31,676,001–32,303,001bps.
