Excluding the SNPs mapping to 15q25.1, 5p15.33 and 6p21.33 loci, the most significant association was provided by rs11264329 and rs2844363 (P = 1.22 × 10−6 and 5.90 × 10−6 respectively), which map to 153,361,782bp on 1q22 and 37,586,864bp on 3p22.2 (Supplementary Table 1). Whilst suggestive of association none were statistical significant imposing the conventionally accepted threshold for genome-wide significance (i.e. 1 × 10−7).