The smallest gene-based P-value was found for the NCAM1 gene. Within this gene, rs4471463 had the lowest SNP P-value, and was also among the top 10 associated SNPs. The forest plot in Figure 2 illustrates the effect of this SNP in each sample. In most samples, the effect is in the same direction, such that the major (T) allele is associated with a decreased risk of lifetime cannabis use. The forest plot for two SNPs with lowest P-values in the other significant gene regions can be found in Supplementary Figure 5.
