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Chunk #23 — Results — Sensory Perception of Chemical Stimulus and Smell

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Pathway analysis of smoking quantity in multiple GWAS identifies cholinergic and sensory pathways.
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The most abundant categories of genes, with regard to the number of genes included, that ALIGATOR identified in the OZALC-NAG and SAGE studies grouped highly similar sets of genes. The biological processes GO:0007608, its ancestor the term GO:0007606 and the molecular function term GO:0004984 shared 368 genes in common (Table 3). From the pool of 431 different genes grouped by these terms, 56 were significant for at least two studies (Figure S2), and 7 genes were common to all three studies. This list includes the glutamate receptors, metabotropic 7 (GRM7– chr. 3p26.1-p25.1) and 8 (GRM8– chr. 7q31.3-q32.1); the olfactory receptors OR10P1 (chr. 12q13.2); OR52E2 (chr. 11p15.4), OR52J3 (chr. 11p15.4), and OR8D4 (chr. 11q24.1); and the bitter taste receptor TAS2R1 (chr. 5p15).