The MAGENTA algorithm only identified GO terms related to cholinergic nicotinic genes (See Table 4 for significance results, and Table S4 for false discovery rates). Seven of the terms identified for OZALC-NAG and SAGE were also significant in ARIC (nominal p-value<0.05). Moreover, three of these terms were previously detected by ALIGATOR (i.e., GO:0015464, GO:0005892 and GO:0004889). In contrast to the other terms detected by MAGENTA, the term GO:0005230, ancestor of GO:0005230, includes genes other than the cholinergic receptors. However, none of these seven terms remained significant in any study when we performed the analysis dropping the clusters of cholinergic genes located in chromosomes 15 and 8, indicating that this core of cholinergic nicotinic receptors drives the results observed using MAGENTA.
