a reduced dataset that did not include these genes (i.e., we removed CHRNA5-A3-B4 and CHRNB3-A6 genes). Although there was a considerable difference in the significance, the terms GO:0005892, GO:0042166 and GO:0004889 showed p-values <0.05 for SAGE (i.e., 0.014, 0.02 and 0.014 respectively) and a marginal p-value of 0.056 for the term GO:0015464. In the OZALC-NAG study, the term GO:0015464 showed a p-value of 0.049, and the term GO:0042166 a marginal p-value of 0.06. None of these terms was significant in ARIC, which reported the fewest significant genes for these terms (Table 3; and Figure 1), and only included 4 genes (CHRNA7/9 and CHRM4/1) after dropping the genome-wide significant genes.
