that divergent methods produce convergent results provides compelling evidence for the developmental and gene-by-environment effects reported here. Further, polygenic approaches have the advantage of providing a more global index of genetic risk goes beyond widely-criticized and only nominally informative candidate gene studies (Duncan & Keller, 2011). Although polygenic approaches do not—by design—identify specific genes associated with an outcome, complementary methods such as gene set analyses may identify the potential biological mechanisms underlying their effects (e.g., through examination of whether SNPs included in polygenic scores are located in functionally related genes (Wang, Jia, Wolfinger, Chen, & Zhao, 2011)). We return to this point shortly.
