We examined the mRNA expression of the glutamate receptor subunits in the caudate from alcoholics and individuals without alcohol dependence. Normalized average expression levels of the different glutamate receptor subunits in the caudate of individuals without alcohol dependence are shown in Figure 1. Qualitatively, the high and medium levels of expression were defined as equal to or greater than that of GluN1 and GluA1, respectively. The results show high expression of GluA2 and GluN1, medium expression of GluA1, GluA3, and GluN2B, and low expression of other glutamate receptor subunit mRNAs.
