(95% CI)p valueSchizophreniaLifetime smokingInverse-variance weighted1020.022 (0.005–0.038)0.009MR Egger (SIMEX)–––Weighted median1020.015 (0.004–0.026)0.009Weighted Mode1020.016 (−0.014 to 0.045)0.31MR RAPS1020.018 (0.003–0.032)0.015DepressionLifetime smokingInverse-variance weighted340.091 (0.027–0.155)0.005MR Egger (SIMEX)–––Weighted median340.100 (0.058–0.141)2.77 × 10−06Weighted mode340.109 (0.037–0.182)0.005MR RAPS340.078 (0.014–0.141)0.016SchizophreniaSmoking initiationInverse-variance weighted1070.010 (0.000–0.021)0.04MR Egger (SIMEX)107−0.030 (−0.093 to 0.033)0.35Weighted median1070.003 (−0.006 to 0.012)0.53Weighted Mode107−0.008 (−0.033 to 0.017)0.54MR RAPS1070.008 (−0.002 to 0.017)0.11DepressionSmoking initiationInverse-variance weighted340.083 (0.039–0.127)2.32 × 10−04MR Egger (SIMEX)–––Weighted median340.077 (0.042–0.112)1.55 × 10−05Weighted mode340.062 (0.007–0.117)0.03MR RAPS340.077 (0. 037–0.117)1.64 × 10−04SIMEX, simulation extrapolation, MR RAPS, robust adjusted profile score.Note: Due to low regression dilution I2GX (see online Supplementary Table S3), MR Egger estimates could not be conducted apart from for the effect of schizophrenia on smoking initiation, where a weighted MR Egger SIMEX was conducted. Smoking initiation scores are given in βs by GSCAN calculated from the meta-analysed z-score statistic by assuming a prevalence for the binary trait (Liu et al., 2019).
