A single train of ten theta bursts, which past studies have shown is well above the threshold (number of bursts) needed to induce LTP21,22 produced a robust and immediate potentiation in wildtype slices that steadily decayed over 10 min to a plateau level that was approximately 60% above the pre-TBS baseline; the mean (± SEM) % LTP for minutes 50-60 post-TBS was 59 ± 4%. Hippocampal slices prepared from Baf53b+/− het mice exhibited a very different pattern: short-term potentiation (STP) was not measurably different from wildtype values but the enhanced responses failed to stabilize and instead gradually fell back to baseline (Fig 5A). Percent facilitation for the last ten minutes of the one hour post-TBS session was 14 ± 6% (p<0.0001 vs. WT).
