To assess the potential contributions of BAF53b in synaptic plasticity, a cellular mechanism thought to underlie memory processes, we examined long-term potentiation in acute hippocampal slices from BAF53bΔHD and Baf53b+/− het mice. Wildtype slices were tested concurrently with a subset of cases for each of the three experimental groups. Results for all wildtype controls (n=24) are included in the summary graphs of the latter groups. Theta burst stimulation (TBS) was delivered to a single collection of Schaffer-commissural fibers in all slices for many of which a second input received only low frequency (3pulses/min) stimulation (LFS). We detected no changes over time in the EPSP slopes elicited by LFS in any of the slice groups (Supplemental FigS4A), and these data are also combined in the data summaries.
