Table 2 lists genes in or near the lead SNP in each region, regional plots are in Supplementary Data 1, and Supplementary Tables 6–7 provide extensive summaries of available information about the biological functions of the genes in each region. In the Supplementary Note we review four key genes in more detail: OLFM4 and NEGR1 (notable for reported associations with obesity and body mass index29–34), RBFOX1 (notable for independent our associations at both the 5′ and the 3′ ends, a splicing regulator35,36, with a functional role that may be consistent with chronic hypothalamic-pituitary-adrenal axis hyperactivation reported in MDD37), and LRFN5 (notable for its role in pre-synaptic differentiation38,39 and neuroinflammation40).
