Gene-wise analyses identified 153 significant genes after controlling for multiple comparisons (Supplementary Table 7). Many of these genes were in the extended MHC region (45 of 153) and their interpretation is complicated by high LD and gene density. In addition to the genes discussed above, other notable and significant genes outside of the MHC include multiple potentially “druggable” targets that suggest connections of the pathophysiology of MDD to neuronal calcium signaling (CACNA1E and CACNA2D1), dopaminergic neurotransmission (DRD2, a principal target of antipsychotics), glutamate neurotransmission (GRIK5 and GRM5), and presynaptic vesicle trafficking (PCLO).
