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Chunk #4 — RESULTS — Replication studies (Stage 2) and global (Stage 1 + Stage 2) meta-analysis for 25 loci

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New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
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We directly genotyped 25 variants in 26 additional Stage 2 studies with up to 63,850 non-diabetic participants of European ancestry for FG, and 25 studies and up to 52,892 participants for FI, HOMA-IR and HOMA-B (Supplementary Table 1b, Online Methods). We also obtained in silico replication data for 12,708 additional individuals from seven studies for FG (9,372 participants and five studies for FI, HOMA-IR and HOMA-B), for a total of up to 76,558 individuals for FG and 62,264 for FI, HOMA-IR and HOMA-B in Stage 2 association analyses.