Our combined Stage 1 and 2 meta-analysis, including a total of up to 122,743 participants for FG (98,372 for FI, HOMA-IR and HOMA-B) established genome-wide significant associations for nine novel loci for FG and/or HOMA-B (ADCY5, MADD, CRY2, ADRA2A, FADS1, PROX1, SLC2A2, GLIS3, FAM148B) and one for FI and HOMA-IR (IGF1) (Table 1 and Figure 1a–j). We hereby replicate the recently reported loci DGKB/TMEM195 (FG)24 and GCKR (FG, FI and HOMA-IR)11,12,25 at levels that exceed genome-wide significance. Loci that had previously achieved genome-wide significant associations with FG (G6PC2, MTNR1B and GCK) were also confirmed (Table 1).
