Chunk #21 — Results — Kal7 is expressed in the major neuronal cell types in nucleus accumbens and dorsal striatum — Kal7 is the major Kalirin protein in the dorsal striatum and nucleus accumbens
Kalirin function is altered when Thr1590 is phosphorylated by cyclin dependent kinase 5 (Cdk5), and levels of both Cdk5 and NR2B are decreased in PSDs prepared from Kal7KO animals [17,30]. We therefore compared levels of NR2B and Cdk5 in these three brain regions (Figure 5); similar levels of both proteins were detected in all three regions. We also examined levels of Rac1, one of the major substrates of Kal7, in the same brain regions; again, no dramatic differences were observed (Figure 5).
