Chunk #43 — RESULTS — Transcription factors register the developmental history and contribute to the maintenance of PCP phenotypes — GABAergic neurons retain a transcription resume that registers their developmental history
Furthermore, by hierarchical and pair-wise comparison, we defined multiple sets of TFs that distinguish PV vs SST population (Figure 7F), and the PV, SST and VIP pairs of PCPs (Figure 7G). Again, we found evidence for developmental continuity of TF expression from embryonic precursors to mature neurons (Figure S7C). In particular, multiple PVBC-enriched TFs initiate expression at different stages of development, from Lhx6 and its downstream cascade (Figure 7A, D–E) to Ssbp2, Nfib and PGC1α (Figure 7E–G; (Batista-Brito et al., 2008), indicating that they maintain sequentially acquired transcriptional factors (Figure 7A).
