Chunk #44 — RESULTS — Transcription factors register the developmental history and contribute to the maintenance of PCP phenotypes — GABAergic neurons retain a transcription resume that registers their developmental history
These results suggest that PCPs register the developmental history of their transcription program, i.e. a “transcription resume”, through sustained expression of sequentially accumulated transcription factors. Conditional deletions of several of these TFs in adult cortex result in the loss of markers and physiological properties characteristic to their identity (e.g. (Close et al., 2012; Touzot et al., 2016), suggesting their requirement in mature neurons to maintain aspects of cell phenotypes and identity.
