Chunk #45 — RESULTS — Transcription factors register the developmental history and contribute to the maintenance of PCP phenotypes — The PGC1a transcription program coordinates the release and metabolic properties of PV cells
The fast input-output transformation of PVBCs requires specialized energy metabolism and mitochondria features (Lucas et al., 2014). The transcription coactivator PGC1α cooperates with multiple transcription factors to regulate mitochondria biogenesis and energy metabolism (Lin et al., 2005). In the brain, it is largely restricted to cortical PVBCs and may directly regulate genes involved in mitochondria function and transmitter release (Lucas et al., 2014). Several PGC1a co-factors (e.g. Rora, Esrrg, Pparg) and all of its potential targets (PV, Syt2, Nefh, Cplx1, Atp50, Atp5a1) (Lucas et al., 2014) are substantially enriched in PVBCs (Figure 7J, S7D). We further found an extended set of PVBC enriched mRNAs associated with metabolic and mitochondria pathways (e.g. Fndc5, Cox6a2, Cox6c, Cox7b; Figure 7J). These results suggest that PGC1α might organize a transcription module that coordinates the release and metabolic properties in PVBCs.
