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Chunk #6 — Methods — Subjects

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Validating Harmful Alcohol Use as a Phenotype for Genetic Discovery Using Phosphatidylethanol and a Polymorphism in ADH1B.
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PEth, we included participants for whom AUDIT-C data were available in the EHR and who had PEth values (n=1,851). The analysis comparing AUDIT-C to presence/absence of the ADH1B 369Cys allele was limited to 1,503 AAs with genotype and AUDIT-C data, as this particular variant is rare in most other racial/ethnic groups. In this sample, the 369Cys allele was present in 36% of AAs, 0.3% of whites, and 6% of all others. A total of 1,342 participants were in both analytic samples.