format and subjected to further QC, where SNPs were removed if they exhibited poor imputation quality (INFO <0.8), low MAF (<1%), deviations from HWE (P < 1 × 10−10) or missingness (variant call rate <98%). Only unrelated individuals (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\hat{\mathrm{p}}}$$\end{document}p^ < 0.2) of EUR ancestry were included in the present study. These procedures yielded a final analytic sample of 25,698 individuals in the MGBB.