To appreciate how the patch/matrix distinction affects pathway specialization, we compared gene loadings across the patch-encoding ICs for dSPNs and iSPNs (Figure S7C). We observed classic (Tac1) and undescribed (Tshz1) pan-patch markers (Figure S7D) as well as genes enriched in either iSPN (Asic4) or dSPN (Necab1) patches (Figure S7E). Our data suggest complex SPN specializations across pathways and compartments: the transcriptional features endowed by patch compartments are not identical for dSPNs and iSPNs, and some of these differences appear to eliminate pathway expression differences found in the matrix dSPNs and iSPNs (Figure S7E).
