(n=245,123) and AFR (n=62,034) populations (from which study subjects were drawn based on availability of phenotype information). Specifically, the subjects with a probability cut off of 0.9 relative to the genetic component observed in YRI (Yoruba in Ibadan, Nigeria; West Africa) or LWK (Luhya in Webuye, Kenya; East Africa) in the admixture analysis and the AFR samples of the 1,000 Genomes Project indicated the genetic diversity cluster for African-Americans on the pairwise PC-based scatter plots. The MVP subjects enclosed in the AFR cluster on the scatter plots of PC1 to PC4 are identified as the African-Americans, whose probabilities of being YRI or LWK from the admixture analysis are >0.6. Similarly, the EUR cluster in the pairwise PC-based scatter plots is defined by the subjects with a probability cut off of 0.9 relative to the genetic component observed in GBR (British in England and Scotland) and the EUR samples of the 1000 Genomes Project; the MVP samples within the EUR cluster in the PC-based plots are identified as European-Americans, whose probabilities of being GBR from the admixture analysis are >0.8.
