We used FUMA (Watanabe et al., 2017) to map SNPs to genes and then test for enrichment of specific Gene Ontology functions and pathways among genome-wide significant pleiotropic and disorder-specific SNPs separately. Hypergeometric tests identify any statistical over-representation of genes from the input list (mapped from SNPs) in predefined MSigDB Gene Ontology gene sets which describe biological processes, molecular functions, and cellular components. Multiple test correction was applied by category.
