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Chunk #25 — DISCUSSION

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Associations between alcohol use disorder polygenic score and remission in participants from high-risk families and the Indiana Biobank.
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extends to individuals in non-abstinent remission, who have lower severity and PGSAUD on average than individuals in abstinent remission, as well as to abstinent remission. These findings indicate that, just as PGSAUD and family history of AUD are complementary to each other in evaluating the risk for AUD (Lai et al., 2022a), so PGSAUD and family history of remission capture distinct sources of variability in evaluating the probability of remission. Furthermore, PGSAUD might be useful for individuals who are unaware of their family history due to separation from family (e.g., adopted) or family denial of alcohol problems (Schuckit et al., 2020).