That family history of remission was associated with increased probability of abstinent and non-abstinent remission in COGA EA and AA independent of PGSAUD, which partitioned out genetic influences on AUD, suggests that family history could potentially index genetic and social influences that affect remission separately from AUD. Our previous work found that a family history of abstinent (but not non-abstinent) remission in a first-degree relative was associated with increased probability of remission independent of AUD severity, professional treatment and mutual help participation (McCutcheon et al., 2017). In that study, the first-degree relatives were all probands who had been recruited from AUD treatment, most of whom were abstinent if they were remitted. The current study extends that work with the inclusion of PGSAUD, showing that family history of remission is significant independent of measured genetic influences on AUD, and that it extends to individuals in non-abstinent remission, who have lower severity and PGSAUD on average than individuals in abstinent remission, as well as to abstinent remission. These findings indicate that, just as PGSAUD and family history of AUD are complementary to
