Although the network measures of BD patients were significantly altered in the alpha band (i.e., decreases of C and Eg, and increase of L), no group differences for γ and λ were found. Mathematically, because changes in functional connectivity (i.e., decrease of mean SL value) are likely to influence network measures, both C and L directly depend on the SL weight itself (cf. the formula in the supplementary material). Therefore, the lower mean SL of the BD network will result in the decrease of C and the longer L. However, no significant differences were found for the normalized measures: only non-significant trends for network alterations were observed. It is also possible that BD patients and healthy controls may have their own random counterpart respectively, and that the topological pattern of the BD network (if excluding the weight difference) might not differ from that of healthy controls. BD patients may have subtle topological deficits compared to neurodegenerative diseases that typically show distinct topological differences, such as Alzheimer's disease (Lo et al., 2010; Stam et al., 2007a, 2009).
