in the topological alteration of brain network, may reflect dysfunction of GABAergic interneurons in BD patients (Benes and Berretta, 2001). An interpretative issue is the possible effect of medication on GABAergic transmission and EEG activity. Because anticonvulsant mood stabilizers as well as lithium typically upregulate GABA levels or activities, this medication might impact the alpha frequency activity (Benes and Berretta, 2001; Beneyto et al., 2007; Brambilla et al., 2003).
