This study is comprised of two stages. Stage 1 is a meta-analysis of GWA studies comprised of 32,387 individuals of European ancestry. This meta-analysis allowed us to select 35 loci for detailed examination in stage 2, which included direct genotyping in 45,018 European-origin individuals from nine studies and in silico comparisons with results from 14,064 European-origin individuals from five studies with GWA data (Supplementary Fig. 1 and Supplementary Table 1).
