× 10−4, P<1 × 10−3, P<0.01, P<0.05 and P<0.5). Next, linear/logistic regression was conducted to predict neuroticism from the PGS in 8,648 NTR participants and MDD status in 1,859 unrelated MDD cases and 2,391 unrelated controls from NTR and NESDA. MDD case-control status was defined as a lifetime DSM-IV diagnosis using the Composite International Diagnostic Interview (CIDI). Age, sex and nine PCs were included as covariates. See for more details eMaterials and methods.
