Meta-analysis of GWA results across the 29 cohorts revealed one genome-wide significant SNP (rs35855737; P=9.26 × 10−9). The SNP is located in an intron of the MAGI1 gene (Figure 1). The pooled regression effect was −0.04 with the minor allele C coded as the effect allele (Figure 2). Imputation quality was very high (r-squared or proper_info>0.94) in all cohorts, except in ERF (r2=0.63). MAF of the SNP ranged from 0.13 to 0.22 across cohorts with imputation quality >0.94 and showed a mean of 0.18 (SD=0.02), which corresponds to the MAF for this SNP in the 1000G reference set. MAF in the ERF cohort was 0.07. Eleven other SNPs in the MAGI1 gene showed suggestive genome-wide significance (P<1 × 10−5); all SNPs were intronic; one SNP was in very high LD with rs35855737 (rs1404544; r2>0.80; P=8,59 × 10−6) and three SNPs were in high LD with rs35855737 (rs1524970, rs1880522 and rs6799284; r2>0.60, 3.64 × 10−6 < P < 8.54 × 10−7). The Manhattan and quantile-quantile plots are given in Figures 3 and 4. A list with all 127 suggestively genome-wide significant
