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Chunk #10 — Limited generalizability of PRS across diverse populations

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Clinical use of current polygenic risk scores may exacerbate health disparities.
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blood panel traits in the UK Bio bank (UKBB) when using European-derived summary statistics (Supplementary Note). Consistent with previous studies, we find that relative to European prediction accuracy, genetic prediction accuracy was far lower in other populations: 1.6-fold lower in Hispanic/Latino Americans, 1.7-fold lower in South Asians, 2.5-fold lower in East Asians, and 4.9-fold lower in Africans on average (Figure 3).