Early diversifying GWAS efforts have been especially productive for informing on questions surrounding risk prediction. Rather than varying the prediction target dataset, some GWAS in diverse populations have increased the scale of non-European summary statistics and also varied the study dataset in multi-ethnic PRS studies23,24,40. These studies have shown that even when non-European cohorts are only a fraction the size of the largest European study, they are likely to have disproportionate value for predicting polygenic traits in other individuals of similar ancestry.
