Irregular pattern of heavy alcohol consumption, assessed as binge drinking, was associated with risk of pancreatic cancer (Table 3). A history of binge consumption of large amounts of alcohol (≥5 drinks per drinking episode or >70 g alcohol per episode) [50, 51] conferred a 3.5-fold increased risk of pancreatic cancer in men. Risk was increased regardless of age when binge drinking first occurred, although there was some evidence that risk was greatest for binge drinking that began at 21–30 years of age (p-trend = 0.007). A similar pattern was observed for years since last binge drinking episode. Risk was increased more than threefold regardless of when binge drinking last occurred, although men whose last binge drinking episode occurred 6–10 years before diagnosis/interview had a greater than sixfold increased risk of pancreatic cancer. Dose–response analyses provided additional support that binge drinking increased risk of pancreatic cancer in men. Risk was positively associated with increasing average number of alcoholic drinks consumed during binge drinking (>15 drinks: OR = 4.4, p-trend = 0.002) and with increasing years duration of binge drinking (>10 years:
